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Marco Zaccaria: How Do Elastic Centripetal Forces Lead to Dynamic Changes in the Myometrial Free Margin as Regards Submucous Myomas?
Marco Zaccaria/LinkedIn
Jun 12, 2026, 14:08

Marco Zaccaria: How Do Elastic Centripetal Forces Lead to Dynamic Changes in the Myometrial Free Margin as Regards Submucous Myomas?

Marco Zaccaria, Global Product Manager at ESGE European Society Gynecology Endoscopy, shared a post on LinkedIn:

“How do elastic centripetal forces lead to dynamic changes in myometrial free margin as regards submucous myomas?

Myometrial free margin (MFM) is the measurement of the minimum thickness of healthy muscle tissue separating the outer edge of a uterine fibroid from the outer wall of the uterus

When a submucous fibroid (especially Type II with a deep intramural component) is resected, the surrounding uterine wall undergoes three predictable, phase-dependent alterations:

Initial Thinning: as the uterine cavity is distended with saline solution, the increased intrauterine pressure stretches the tissue and this causes the MFM to temporarily decrease to its thinnest point

The Centripetal Effect: as the surgeon removes successive fragments of the fibroid mass, the intrinsic tension within the muscle is progressively released and the healthy, adjacent myometrial fibers spontaneously contract and retract inward

Safety Margin Expansion: this inward muscular squeeze systematically drives the deep, intramural portion of the fibroid up out of its bed and into the uterine cavity and consequently, the tissue wall behind the tumor thickens dramatically, expanding the margin of safety

Traditionally, a thin preoperative MFM (under 5–10 mm) was viewed as a strict contraindication due to high perforation risks and recognizing this dynamic thickening allows experienced surgeons to operate safely on deep fibroids.”

Marco Zaccaria: How Do Elastic Centripetal Forces Lead to Dynamic Changes in the Myometrial Free Margin as Regards Submucous Myomas?

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elastic centripetal forces Fertility Fertility News fibroid mass healthy muscle tissue Initial Thinning intramural component intramural portion intrauterine pressure Marco Zaccaria MFM muscular squeeze myometrial fibers Myometrial free margin reproductive health Reproductive Medicine Safety Margin Expansion saline solution submucous fibroid submucous myomas successive fragments The Centripetal Effect Uterine cavity uterine fibroid
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