Sloboda Lab: High-Fat, High-Sugar Diet Before Pregnancy Impacts Placental Health and Fetal Development
Deborah Sloboda, Professor at McMaster University, shared a post on LinkedIn:
“New paper alert!
Dr Christian Bellissimo, newly minted PhD graduate from the Sloboda Lab shows that when pregnancy begins in the context of excess adiposity, the placenta experiences lower oxygen and subtle tissue injury. Using a preconception high-fat, high-sucrose mouse model, we mapped placental oxygen levels and found:
- Reduced placental oxygenation in both major placental zones • Localized calcification and inflammation
- Altered immune and endocrine signals reaching the fetus
- Sex-specific fetal inflammatory responses
These findings reinforce a key concept in early life programming: that the intrauterine environment is shaped long before implantation and it influences offspring health trajectories. So healthy pregnancy starts before conception.
So proud of my team for this collaborative work at the intersection of metabolism, placental biology, and developmental programming.
Published in Biology of Reproduction
–> Check it out!”
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Jun 15, 2026, 12:21Zara Grigoryan: Open Expert Dialogue to Shape Women’s Health in Armenia
-
Jun 15, 2026, 12:12Abhishek Saxena։ Can a 5PN Embryo Develop Normally?
-
Jun 15, 2026, 12:02Does Growth Hormone Help in IVF? – Fertility Plus
-
Jun 15, 2026, 11:55Allen Morgan: PRP in Fertility Treatment, Emerging Evidence and Future Directions
-
Jun 15, 2026, 11:49Hereditary Gynecologic Cancer Care Is Evolving, but Access and Health Systems Remain Unequal – IJGO
-
Jun 15, 2026, 11:41Celebrating Community and Support at the Annual Fertili’Tea Party! – CFAS
-
Jun 15, 2026, 11:37Christopher Robinson: Outcomes in Late Preterm and Term Births with Gestational Diabetes vs Normoglycemia
-
Jun 15, 2026, 11:34Registration Now Open for Fertility 2027 – British Fertility Society
-
Jun 15, 2026, 11:28Ioakeim Sapantzoglou: Excited to Share Our Latest Publication in Archives of Gynecology and Obstetrics!