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Nicola Pozzi: A New Mechanism to Reduce Thrombus Formation Without Increasing Bleeding Risk
Nicola Pozzi/LinkedIn
Mar 16, 2026, 12:55

Nicola Pozzi: A New Mechanism to Reduce Thrombus Formation Without Increasing Bleeding Risk

Nicola Pozzi, Associate Professor of Saint Louis University School of Medicine, shared a post on LinkedIn:

“From structure, to function, to proof-of-concept therapeutic. A brand-new mechanism to reduce thrombus formation without increasing bleeding risk inspired by our research on Antiphospholipid Syndrome (APS).ss

Extremely proud of this work, how it has evolved over the years and the incredible people involved (Marisa Brake, PhD, Suresh Kumar, PhD Catherine Lapointe, Glenn Merrill-Skoloff, Sol Schulman, Matthew Flick, and Robert Flaumenhaft at Harvard Medical School, Saint Louis University School of Medicine and Blood Research Center at UNC)

We believe this approach has great potential, and we’re excited to moving it forward. Also, here’s an interesting research question. Are all autoantibodies bad? Early to say but maybe not all of them are…”

Title: In vivo targeting of open prothrombin with the monoclonal antibody POmAb results in anticoagulation without excessive bleeding

Authors: Marisa A. Brake, Suresh Kumar, Catherine Lapointe, Glenn Merrill-Skoloff, Sol Schulman, Matthew J. Flick, Robert Flaumenhaft, Nicola Pozzi

Nicola Pozzi: A New Mechanism to Reduce Thrombus Formation Without Increasing Bleeding Risk

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Antiphospholipid Syndrome APS autoantibodies bleeding risk Blood Research Center Fertility Fertility News Glenn Merrill-Skoloff Harvard Medical School Marisa Brake Matthew Flick Nicola Pozzi PhD PhD Catherine Lapointe proof-of-concept reproductive health Reproductive Medicine Saint Louis University School of Medicine Sol Schulman Suresh Kumar Thrombosis UNC
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