Timothy Glidewell: New Discoveries in Mucosal Immunity and HIV Defense
Timothy Glidewell, Spatial Regional Account Manager at Bruker Spatial Biology, shared a post on LinkedIn:
“New discoveries in mucosal immunity and HIV defense
A recent study has uncovered how innate lymphoid cells (ILCs) in the female genital tract act as frontline defenders against HIV.
Using the CellScape Precise Spatial Multiplexing platform, researchers revealed:
ILC1s and ILC3s dominate distinct regions of the tract
Endometrial NKp44+ ILC3s form lymphoid aggregates with T and B cells
ILCs are preloaded with antiviral cytokines (IFNγ, IL-22) even at rest
Within just 30 minutes of HIV exposure, ILCs mount rapid, subset-specific antiviral responses — unlike T or NK cells
Why this matters:
This is the most comprehensive spatial map to date of ILCs in the female genital tract. The findings highlight how immune defenses are shaped by age and reproductive history, and how ILCs may serve as immediate mucosal barriers to HIV infection.
By enabling high-plex, spatially resolved immune profiling, CellScape made it possible to visualize these rare immune cell subsets in situ and uncover their role in mucosal protection.
See the publication here.”
Title: Spatial and functional diversity of innate lymphoid cells in the human female genital tract may contribute to antiviral responses to HIV
Authors: Alexandra Werner, Laura Moreno de Lara, Aleah Holmes, Siddharth Parthasarathy, Genna E. Moldovan, Anna Borchers, Francisco J. Carrillo-Salinas, Jared M. Fortier, Vidya Iyer, Alison Vogell, Rebecca Jameson, Jacquelyn Stephens, Marta Rodriguez-Garcia
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