Christopher Robinson: Immune Tolerance Breakdown In Pregnancy!
Christopher Robinson, Associate Professor Maternal Fetal Medicine at University of South Carolina, shared a post on LinkedIn:
“AJOG Expert Review: Immune tolerance breakdown in pregnancy: transplantation parallels in chronic intervillositis and villitis of unknown etiology – Schematic representation of immune dysregulation in villitis of unknown etiology (VUE)
The decidua and intervillous space exhibit a dominant infiltration of maternal CD8+ T cells, expressing the chemokine receptor CXCR3, alongside scattered histiocytes and CD4+ T cells. These CD8+ T cells target chorionic villi abnormally expressing polymorphic HLA molecules. The villous stroma is infiltrated by CD8+ T cells causing structural damage. Fetal Hofbauer cells become activated and express HLA class II molecules. The fetal endothelium also shows aberrant expression of polymorphic HLA. These findings are consistent with a T cell–mediated rejection (TCMR) phenotype.
Title: Immune tolerance breakdown in pregnancy: transplantation parallels in chronic intervillositis and villitis of unknown etiology
Authors: Pierre Hannoun, Alexandra Benachi, Marion Rabant, Cédric Usureau, Jean-Luc Taupin, Julien Zuber
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Oct 13, 2026, 16:58Slavian Bumbu: A Low AMH Is Not an Infertility Diagnosis
-
Oct 13, 2026, 16:43Keshav Malhotra: No Embryologist or Laboratory Technique Can Guarantee Euploid Embryos
-
Oct 13, 2026, 16:37Tony Gordon: What Is the Most Successful Form of Fertility Treatment?
-
Oct 13, 2026, 16:29IVI RMA Global Introduces IVI Fertility
-
Oct 13, 2026, 16:12Devyanshi Dixit: PCOS May Be One Diagnosis, But Is It One Biological Disease?
-
Oct 13, 2026, 16:00Rajeev Agarwal: Age and Male Fertility, Through the PREPARE Method
-
Oct 13, 2026, 15:505 Years of the Patient Engagement Forum – HFEA
-
Oct 13, 2026, 15:41Cell-Free Fetal DNA Testing for Single-Gene Conditions – RCOG
-
Oct 13, 2026, 15:24Somil Singhal: Method for Enhancing Embryo Implantation Using Embryo Glue and Its Importance