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Why Each Follicle Leaks More Progesterone? – Fertility Plus

Fertility Plus/LinkedIn

Jul 12, 2026, 15:37

Why Each Follicle Leaks More Progesterone? – Fertility Plus

Fertility Plus shared a post on LinkedIn:

“Low Ovarian Response: Why Each Follicle Leaks More Progesterone

This picture explains a surprising twist. You might assume that a woman who grows only a few follicles would always have low progesterone, but the opposite can happen. When the ovary responds poorly, doctors often use high doses of FSH to coax those few follicles along. That intense FSH drive pushes the granulosa cells of each follicle to work flat out, switching the progesterone-making enzyme up to maximum.

The result is that each single follicle leaks a disproportionately large amount of progesterone. Measured per follicle, low responders actually produce the most progesterone of any group, the highest progesterone-to-follicle ratio. The picture shows the few follicles surrounded by a dense cloud of FSH, with progesterone pouring out of each one. It also notes a second, less certain idea: that the follicles in a low-reserve ovary may be slightly older, or ageing, which could add to the early progesterone. That ageing idea is clearly labelled a hypothesis, meaning it is a reasonable proposal still being tested rather than a proven fact.”