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Kenji Ezoe: Can Prolactin Improve Embyo Transfer Outcomes?
Kenji Ezoe/LinkedIn
Mar 30, 2026, 12:10

Kenji Ezoe: Can Prolactin Improve Embyo Transfer Outcomes?

Kenji Ezoe, Senior Scientist at  Kato Ladies Clinic, shared a post on LinkedIn:

“New Publication

Can prolactin improve embryo transfer outcomes?

Our randomized controlled trial, recently published in Reproductive BioMedicine Online, explored the effect of combining prolactin (PRL) with a hyaluronic-acid–enriched transfer medium (EmbryoGlue) for single vitrified-warmed blastocyst transfer (SVBT).

In a double-blind RCT of 1,236 couples, the EGP group (EmbryoGlue + PRL) showed:

  • Higher live birth rate
  • Higher ongoing pregnancy rate
  • Lower early pregnancy loss

compared with both the control and EmbryoGlue groups, with no increase in adverse outcomes.

These findings suggest that PRL supplementation during embryo transfer may help improve live birth outcomes by reducing early pregnancy loss.

Read more.”

Title: Post-warming culture and single vitrified-warmed blastocyst transfer with hyaluronic acid and prolactin: a randomized controlled trial

Authors: Kenji Ezoe, Tetsuya Miki, Nanoha Fujiwara, Satoshi Ueno, Mika Narisawa, Kiyoe Shimazaki, Ryosuke Akino, Shogo Nishii, Sachie Onogi, Satoshi Tsuchiyama, Keiko Wada, Tomoko Kuroda, David K. Gardner, Keiichi Kato

 

Kenji Ezoe: Can Prolactin Improve Embyo Transfer Outcomes?

Stay updated on all scientific advances in the field of fertility with Fertility News.

Adverse Outcomes controlled trial David K. Gardner double-blind RCT EGP group embryo transfer EmbryoGlue EmbryoGlue + PRL Fertility Fertility News hyaluronic-acid–enriched transfer medium Keiichi Kato Keiko Wada Kenji Ezoe Kiyoe Shimazaki live birth rate Mika Narisawa Nanoha Fujiwara pregnancy loss pregnancy rate PRL PRL supplementation Prolactin Reproductive BioMedicine Online reproductive health Reproductive Medicine Ryosuke Akino Sachie Onogi Satoshi Tsuchiyama Satoshi Ueno Shogo Nishii single vitrified-warmed blastocyst transfer SVBT Tetsuya Miki Tomoko Kuroda
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