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Nael Ismail: Unraveling Genetic Causes of Recurrent Pregnancy Loss
Nael Ismail/LinkedIn
Nov 19, 2025, 01:21

Nael Ismail: Unraveling Genetic Causes of Recurrent Pregnancy Loss

Nael Ismail shared a post on LinkedIn:

“The document discusses two separate studies that used optical genome mapping (OGM) technology to investigate the causes of recurrent pregnancy loss (RPL).

The first study, led by Debopriya Chakraborty, found an average of 40 structural changes in the genomes of RPL patients, and in some cases, these changes directly affected genes linked to RPL and infertility.

The second study, led by Amira Othman, focused on fragile sites in the human chromosome, which are prone to breaks and contribute to genetic instability, and explored their connection to RPL cases.

The document also provides some background information on pregnancy loss, noting that it may occur in up to 25% of all pregnancies, with about half of the cases being caused by genetic or chromosomal issues.

Recurrent pregnancy loss, defined as three or more consecutive pregnancy losses, often has unknown causes, but the new research using OGM technology aims to shed light on these hidden causes.”

Read the full article.

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Amira Othman Assisted Reproductive Technology Chromosomal abnormalities Chromosomal Fragile Sites Clinical Genetics Debopriya Chakraborty Fertility Fertility Challenges Fertility News Genetic Factors Genetic Instability Genetic Issues Genetic Testing Genomic Studies infertility Infertility Management maternal health Nael Ismail OGM Technology Oncology Research Optical Genome Mapping Pregnancy Loss Research Pregnancy Outcomes Recurrent Pregnancy Loss reproductive health RPL Causes Structural Changes Women’s Health
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