NewsFeed
Headlines ASRM ESHRE FIGO ACOG Fertility and Sterility PCOS
November, 2026
November 2026
M T W T F S S
 1
2345678
9101112131415
16171819202122
23242526272829
30  
Rahul Manoj: How Do We Get Abnormal Sperm
Abnormal sperm/gracefertility.in
Nov 4, 2025, 10:02

Rahul Manoj: How Do We Get Abnormal Sperm

Rahul Manoj, Senior Embryologist at Best Life Fertility Center, shared a post on LinkedIn:

“Day 36 — How Do We Get Abnormal Sperm?

Every semen sample tells a story – and when sperm morphology or motility is compromised, the cause often begins long before ejaculation. Understanding the origins of abnormal sperm helps embryologists trace quality issues and guide better patient interventions.

Where Do Abnormal Sperm Originate?

1. Testicular Level (Spermatogenesis Errors):

Genetic or chromosomal defects (e.g., Y-chromosome microdeletions, Klinefelter’s).

Varicocele causes an increased scrotal temperature, which impairs spermatid maturation.

Exposure to toxins, radiation, or infections can lead to meiotic errors and vacuolized heads.

2. Epididymal Maturation Defects:

Incomplete membrane remodeling or cytoplasmic droplet retention leads to poor motility.

Oxidative stress during transit causes mitochondrial dysfunction.

3. Systemic and Environmental Factors:

Smoking, alcohol, obesity, and high heat exposure reduce sperm quality via ROS production.

Certain medications (chemotherapy, anabolic steroids) suppress spermatogenesis.

Nutritional deficiencies (zinc, selenium, folate) affect chromatin packaging.

4. Post-Ejaculation Factors:

Improper liquefaction or high seminal viscosity hinders motility assessment.

Delay in sample processing increases oxidative damage.

Most importantly ‘abnormal sperm‘ are not just morphologically different — they’re functionally compromised. Identifying the root cause (testicular, systemic, or iatrogenic) can improve both treatment choice and lab strategy.”

Abnormal Sperm

Stay updated on all scientific advances in the field of fertility with Fertility News.

Abnormal Sperm anabolic steroids Aphrodite criteria for male infertility management chemotherapy chromosomal defects Epididymal Maturation Fertility Fertility News Klinefelter’s mitochondrial dysfunction Nutritional deficiencies oxidative stress Rahul Manoj ROS production Spermatogenesis Errors Testicular Level Varicocele Y-chromosome microdeletions
NewsFeed